2015 ~ 2024
Zhang H, Okuyama H, Jain A, Jadhav RR, Wu B, Sturmlechner I, Morales J, Ohtsuki S, Weyand CM, Goronzy JJ. PREX1 improves homeostatic proliferation to maintain a naïve CD4 T cell compartment in older age. JCI Insight. 2024. doi.org/10.1172/jci.insight.172848
Jin J, Mu Y, Zhang H, Sturmlechner I, Wang C, Jadhav RR, Xia Q, Weyand CM, Goronzy JJ. CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging. Nat Aging. 2023. doi.org/10.1038/s43587-023-00399-w
Cao W, Sturmlechner I, Zhang H, Jin J, Hu B, Jadhav RR, Fang F, Weyand CM, Goronzy JJ. TRIB2 safeguards naive T cell homeostasis during aging. Cell Rep. 2023. doi.org/10.1016/j.celrep.2023.112195
Zhang H, Jadhav RR, Cao W, Goronzy IN, Zhao VT, Jin J, Ohtsuki S, Morales J, Hu Z, Greenleaf WJ, Weyand CM, Goronzy JJ. Aging-associated HELIOS deficiency in naïve CD4 T cells alters chromatin remodeling and promotes effector cell responses. Nat Immunol. 2022. doi.org/10.1038/s41590-022-01369-x
Lambert S, Cao W, Zhang H, Colville A, Liu J, Weyand CM, Goronzy JJ, Gustafson CE. The influence of three-dimensional structure on naïve T cell homeostasis and aging. Front Aging. 2022. doi.org/10.3389/fragi.2022.1045648
Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021. Review. doi.org/10.1111/febs.15770
Zhang H, Weyand CM, Goronzy JJ, Gustafson CE. Understanding T cell aging to improve anti-Viral immunity. Curr Opin Virol. 2021. Review. doi.org/10.1016/j.coviro.2021.09.017
Jin J, Zhang H, Weyand CM, Goronzy JJ. Lysosomes in T Cell Immunity and Aging. Front Aging. 2021. Review. doi.org/10.3389/fragi.2021.809539
Jin J, Kim C, Xia Q, Gould TM, Cao W, Zhang H, Li X, Weiskopf D, Grifoni A, Sette A, Weyand CM, Goronzy JJ. Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol. 2021. doi:10.1126/sciimmunol.abg0
Ye Z, Gould T, Zhang H, Jin J, Weyand CM, Goronzy JJ. The GSK3β-β-catenin-TCF1 pathway improves naïve T cell activation in old adults by upregulating miR-181a. NPJ Aging Mech Dis. 2021. doi.org/10.1038/s41514-021-00056-9
Fang F, Cao W, Zhu W, Lam N, Li L, Gaddam S, Wang Y, Kim C, Lambert S, Zhang H, Hu B, Farber DL, Weyand CM, Goronzy JJ. The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age. Cell Rep. 2021. doi.org/10.1016/j.celrep.2021.109981
Jin J, Li X, Hu B, Kim C, Cao W, Zhang H, Weyand CM, Goronzy JJ. FOXO1 deficiency impairs proteostasis in aged T cells. Sci Adv. 2020. doi:10.1126/sciadv.aba1808
Yanes RE, Zhang H, Shen Y, Weyand CM, Goronzy JJ. Metabolic reprogramming in memory CD4 T cell responses of old adults. Clin Immunol. 2019. doi.org/10.1016/j.clim.2019.07.003
Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CC, Goronzy JJ. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018. doi.org/10.1016/j.celrep.2018.10.074
Wang H, Li S, Zhang H, Wang Y, Hao S, Wu X. BLM prevents instability of structure-forming DNA sequences at common fragile sites. PLoS Genet. 2018. doi.org/10.1371/journal.pgen.1007816
Zhang H, Rigo F, Martinson HG. Poly(A) signal-dependent transcription termination occurs through a conformational change mechanism that does not require cleavage at the poly(A) site. Mol Cell. 2015. doi.org/10.1016/j.molcel.2015.06.008
